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        Nc2Eye

           A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of retinoblastoma (RB)
ncRNA name hsa-miR-137
ncRNA Category miRNA
Disease name retinoblastoma (RB)
Species Homo sapiens
Tissues/Cell_line RB samples, normal retina tissues; RB cell lines WERI-RB1, Y79, SO-RB50 and HXO-RB44; RPE cell line ARPE-19
Methods qRT-PCR, transfection, CCK-8 assay, colony formation assay, transwell assay, Western blot, luciferase reporter assay
Expression pattern down-regulated
Functional description miR-137 suppresses the proliferation and invasion of RB cells by targeting COX-2/PGE2.
PubMed ID 29945115
Year 2018
Title The down-regulation of microRNA-137 contributes to the up-regulation of retinoblastoma cell proliferation and invasion by regulating COX-2/PGE2 signaling.
Drug-related ncRNA NO

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